The Historic Greenup Depot, built through community effort in 1870, is currently in the museum complex on the Historic National Road. The Depot building has served the St. Louis, Vandalia & Terre Haute Railroad, the Pennsylvania Railroad, the Penn-Central Railroad, and the Illinois Central Railroad. In its current location, the Depot brings to mind a bygone era when railroads brought Greenup many freight shipments and travelers.
The main floor boasts the original waiting room, office fixtures and a model railroad depicting major periods of American Railroading. This depot is one of few constructed with second-story living quarters, currently beautifully restored in 1930’s era decor.