DeSoto House Hotel
230 South Main Street, Galena, IL 61036
Hotels & Motels
Stay the night at the DeSoto House Hotel on Galena’s Main Street, which dates back to 1855 and is Illinois’ oldest operating hotel, featuring 55 Victorian-style guest rooms, three restaurants and boutiques and enclosed guest parking.
Located in the heart of downtown Galena, DeSoto House Hotel offers a one-of-a-kind stay where rich history and timeless charm come together. Opened in 1855, it is the oldest operating hotel in Illinois and was once known as the “largest hotel in the West,” welcoming travelers during Galena’s booming riverfront era. Today, guests can enjoy beautifully appointed Victorian-style rooms, on-site dining, and an unbeatable location along Main Street—just steps from Galena’s shops, restaurants, and historic attractions. The hotel is also a featured stop on tours by Haunted Galena Tour Co., adding an extra layer of intrigue for those interested in Galena’s storied (and sometimes spooky) past.
History enthusiasts can even stay in the room where Ulysses S. Grant once ran his presidential campaign, making for a truly immersive and memorable experience. As one guest shared, “You can feel the history the moment you walk in, it made our stay in Galena even more special!" - Pete K.
Images
More Information
Open 24 hours, 7 days a week
- Restaurant
- Bar/Lounge
- Parking Available
- Wheelchair Accessible
- Daily Housekeeping
- Elevator
- Meeting/Banquet Facilities
- Wi-Fi Available
How to find us?
What's happening nearby...
Galena 46th Annual Halloween Parade
Main Street, Galena • Oct 31 @ 6:30PM
Join Galena's 46th Annual Halloween Parade & Festival! The largest, longest, and spookiest Parade and Festival in the Tri-State Area!
Read more about Galena 46th Annual Halloween Parade
42nd Annual Nouveau Parade & Celebration
Galena Cellars Wine Tasting Room • Nov 20 @ 11AM
Galena Cellars' 42nd Annual Nouveau Celebration features a festive Main Street parade, the release of the 2026 Nouveau wine, and a weekend of live music, wine…
Read more about 42nd Annual Nouveau Parade & Celebration
Galena’s Jeep Jingle
Nov 28 @ 5PM
Celebrate the start of the holiday season in Galena with the Jeep Jingle at 5 PM, Santa’s tree lighting, and an evening of treats, activities, and…
Read more about Galena’s Jeep JingleYou might also be interested...
Irish Cottage Inn & Suites
Galena
Experience the warmth and hospitality of the Emerald Isle while relaxing at the Irish Cottage Inn & Suites, a boutique hotel located just a few miles…
Read more about Irish Cottage Inn & Suites
Eagle Ridge Resort & Spa
Galena
Tucked among The Galena Territory's 6,800 rolling acres of woodlands and open countryside, Eagle Ridge Resort & Spa offers "country elegant" hotel accommodations, rental homes and…
Read more about Eagle Ridge Resort & Spa
Country Inn & Suites By Radisson - Galena
Galena
Stay at one of Galena's finest hotels, offering 75 rooms including specialty suites. Complimentary continental-plus breakfast. Indoor waterpark featuring 72-foot waterslide, whirlpool and wading pool/frog waterslide.
Read more about Country Inn & Suites By Radisson - Galena